Tweaking a Gene Makes Muscles Twice as Strong: New Avenue for Treating Muscle Degeneration in People Who Can't Exercise

According to Daily science studies done by scientist at the Salk Institute for Biological Studies “Tweaking a Gene Makes Muscles Twice as Strong: New Avenue for Treating Muscle Degeneration in People Who Can't Exercise”, studies shows dramatically enhanced muscle tissue in a high performing mouse, which has greater numbers of mitochondria (brown), the energy factories of cells. Through genetic engineering, the mouse developed stronger muscles than normal, even though it was inactive. In the image, a blood vessel (seen in cross section) is red and muscle fibers are blue."



Collaboration between researchers at the Salk Institute for Biological Studies, and two Swiss institutions, Ecole Polytechnique Federale de Lausanne (EPFL) and the University of Lausanne researchers’ team of scientists has created super-strong, high-endurance mice and worms by suppressing a natural muscle-growth inhibitor, suggesting treatments for age-related or genetics-related muscle degeneration are within reach. The scientists found that a tiny inhibitor may be responsible for determining the strength of our muscles. By acting on a genome regulator (NCoR1), they were able to modulate the activity of certain genes, creating a strain of mighty mice whose muscles were twice a strong as those of normal mice. This Gene can aid as an induced drug for diabetic, obesity patience or any other health complications, such as diabetes, immobility and frailty," says Ronald M. Evans, a professor in Salk's Gene Expression Lab, who led the Salk team.