Recombination Hotspots

Meiotic recombination causes sequence polymorphism, which is to thank for genetic variance. Although this is an important process, the mechanism of how it works is poorly understood. Error in recombination can be the cause of chromosomal abnormalities. Knowing where they originate, and how inheritable they are could be important in understanding them.

This article explains three methods of estimating recombination rates which is associated with sequence polymorphism. These methods include: sperm-typing, pedigree data, and linkage disequilibrium. Through the use of these methods, the hotspots can provide information for disease-association studies.