Gene Duplication Detected in Depression

A recent study has shown that a duplicated region of DNA on chromosome 5 predisposes people to depression. This gene is involved in the development of nerve cells, which furthers previous research that disruptions in neurotransmission networks are the basis of depression disorders. Of the copy number variations (CNV) identified in the study, 12 were exclusive to patients with major depressive disorder. A duplication of DNA on chromosome 5 was identified in 5 unrelated cases and was not observed in unaffected controls. This area of chromosome 5 is also the location of the gene SLIT3 which is important for axon development, consistent with the previous understanding that these disorders stem from disruptions in the neuro networks. Future studies with advanced sequencing technology are expected to reveal more CNVs and mutations of the gene SLIT3. In the future these studies may provide the basis for more specific drugs to combat major depressive disorders.