Genetics of Osteoporosis

The Article below contains a small overview into the hunt for the genetics behind Osteoporosis.

I found this to be fascinating  because  although they have not discovered a direct link to the gene or loci the scientists have made a good overview of where they think to begin the search. The disease its self reduces the bone mass and causes some defects in the bone tissues microarchitecture, and we also know from basic information that diet and exercise affect the severeness of the case but genetics seems to also be playing a role in your susceptibility to osteoporosis. Seeing that we now so much about the disease I feel that they are pushing along a good path as to where to begin the search for the gene and loci.

Article written and published by:Stuart H. Ralston^* and André G. Uitterlinden

This older article contains some more information leading to the culprit gene(s) and loci behind Osteoporosis.

http://www.csa.com/discoveryguides/archives/osteo.php

The article featured above is from 1997 explains the four main area that they look for the genetics behind the disease.

I found this information to be quite more  just because it listing actual Ideas and providing back up reasoning to there opinion. the COLIA1 Gene to go further which I found to be even more interesting because of its role playing in the regulatory region with low bone mass and that it was confirmed in three populations. so as they said then there must be a connection to follow further.

following further just a quick article on the COLIA1 gene to explain its role in bone mass density.

http://www.thebonejournal.com/article/S8756-3282(01)00639-1/abstract