Scientists identify new genetic targets for disease research potentially drug development
Thousands of scientists worldwide have analyzed protein-coding genes linking rare DNA alterations to Type II diabetes. From this large set of data, scientists have identified four genes with extremely rare variations in the genetic code that affect the risk of diabetes. With these genes identified, scientists and researches are hoping to find hundreds, if not thousands of more genes that may be connected to other risky diseases and syndromes. This "mapping of mutations" could possibly change the way researchers and scientists diagnose and treat diseases.
The research conducted analyzed 46,000 different individuals from all different ethnic and cultural backgrounds. The group consisted of 21,000 individuals with type II diabetes and 25,000 healthy individuals as control.
The researchers and scientists who conducted this study performed it correctly. Instead of using participants from strictly central Europe, the scientists pulled from a variety of different parts of the globe. "These results demonstrate the importance of studying large samples of individuals from a wide range of ancestries," said senior study author Michael Boehnke, professor of biostatistics and director of the Center for Statistical Genetics at the University of Michigan School of Public Health.
By finding these variants in genes, drug developers and scientist can use this valuable information to help find a cure for diabetes. Diabetes is estimated to be the seventh leading cause of death globally.