New gene discovered could lead to early-onset forms of Alzheimer's Disease

Dominique Campion and his research team have discovered a new gene that could signify early-onset of Alzheimer's Disease. Mutations were found on the gene SORL1, which is on choromosome 11. This gene regulates the production of beta-amyloid peptides, that is used to affect the functioning of brain cells. In the original study including 130 families with early-onset forms, 116 families had mutations of formerly known genes. The unknown mutations of 14 families were then studied further, and showed that 5 out of 14 families had mutation on the SORL1 gene. Seeing this pattern, the researchers have begun to link Alzheimer's Disease to SORL1. A few of the mutations show an increase in beta-amyloid peptides, which contribute to the early onset of Alzheimers.



If this gene in fact plays a major role in the onset of Alzheimer's Disease, it is essential that we experiment quickly and correctly. This will change the lives of everyone; not only will the elderly be affected, but family members will not have to witness the horrific pain associated with watching a loved one forget everything.