Ina study conducted by the University of California San Diego School of Medicine,
personality traits were linked to psychiatric disorders with the use of meta-analysis
of genome-wide association studies (GWAS). Six loci were identified that were
linked to the personality traits: extraversion, neuroticism, agreeableness,
conscientiousness, and openness to experience. The study used data from 23andme,
the Genetics of Personality Consortium, UK Biobank and deCODE Genetics to
analyze genetic variance of the five factors.
Specific loci were identified for the personality traits. For example, extraversion was
association with the gene WSCD2 and near PCDH15. Also, neuroticism was
associated with chromosome 8p23.1 and gene L3MBTL2. Notably, neuroticism and
openness to experience were clustered in the same regions as the psychiatric
disorders looked at. Genetic correlations were found between extraversion and
ADHD, openness and schizophrenia and bipolar disorder, and neuroticism to
depression and anxiety.
Opinion:
I
think this study is important because it helps use better treat psychiatric
disorders by sampling analyzing the phenotypic personality traits. I proves
that there is a correlation so personality can give a hint to susceptibility to
specific disorders. My only concern is that I hope people who have personality
traits associated with the disorders do not experience prejudice.
It is good to see psychiatric conditions being recognized and studied. If we can better understand risk factors for these disorders, we can better understand and medicate against them.
ReplyDeleteI really enjoyed this article, and hope to better understand these conditions at a scientific level. I also believe that some factual evidence for these conditions will clear up a lot of the stigma surrounding mental illnesses. It is also extremely interesting to see the phenotypic relationship with genes that may not have other wise been interpreted as such.
ReplyDelete